What does neurological manifestations mean

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Neurologic Manifestations Definition: Clinical signs and symptoms caused by nervous system injury or dysfunction. Gait Disorders, Neurologic. Neurobehavioral Manifestations. Neuromuscular Manifestations. Pupil Disorders. Reflex, Abnormal. Sensation Disorders. Voice Disorders. Orthostatic Intolerance. Sleep Disorders. Cerebrospinal Fluid Otorrhea. Cerebrospinal Fluid Rhinorrhea. Decerebrate State.

Neurogenic Inflammation. Thus, DHTTs promise to provide patient phenotyping at an order of granularity several times greater than is possible with traditional clinical research tools.

While the conceptual development of novel DHTTs is keeping pace with technological and analytical advancements, an as yet unaddressed gap is how to develop robust and meaningful outcome measures based on sensor data. Here, we describe two roadmaps which were developed to generate outcome measures based on DHTT data: one using a data-centric approach and the second a patient-centric approach.

The data-centric approach to develop digital outcome measures summarizes those sensor features maximally sensitive to the concept of interest, exemplified with the quantification of disease progression. Use cases other than disease progression e. DHTT research requires methods to summarize sensor data into meaningful outcome measures. It is hoped that the concepts outlined here will encourage a scientific discourse and eventual consensus on the creation of novel digital outcome measures for both basic clinical research and clinical drug development.

Research Highlights 23 March Advanced search. Skip to main content Thank you for visiting nature. Atom RSS Feed Neurological manifestations Definition Neurological manifestations refer to neurological signs and symptoms that are caused by a disease or injury that is not primarily neurological. Related Subjects Chronic pain.